Laboratory Testing for Lupus Anticoagulants: A Review of Issues Affecting Results
نویسندگان
چکیده
منابع مشابه
Laboratory testing for lupus anticoagulants: a review of issues affecting results.
BACKGROUND Lupus anticoagulants (LA) are a heterogeneous class of immunoglobulins. Persistent LA positivity is a risk factor for the occurrence and recurrence of venous/arterial thromboembolism and/or pregnancy morbidity and qualifies the patient for anticoagulation therapy. The laboratory diagnosis for LA that is used for crucial decision-making about the optimal duration of the therapy rests ...
متن کاملLaboratory diagnosis of lupus anticoagulants.
Circulating anticoagulants or inhibitors of clotting factors are defined as endogenously produced substances that interfere with various in vitro tests of coagulation. Anticoagulants are usually immunoglobulins, although other endogenous materials, such as heparin or fibrinogen split products, may inhibit in vivo or in vitro coagulation (Table 1). Specific inhibitors are immunoglobulins with ep...
متن کاملA review on the latest clinical and laboratory criteria for clinical diagnosis of Systemic Lupus Erythematosus
Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease with various organs involvement which early diagnosis of disease is critical for successful treatment. The subjects with the possibility of SLE who visit by physician, their full medical history and specific immunological tests should investigate precisely in order to subsequently asses their hematological and renal parameters t...
متن کاملRecent guidelines and recommendations for laboratory detection of lupus anticoagulants.
The International Society on Haemostasis and Thrombosis (ISTH) and the British Committee for Standards in Haematology (BCSH) have recently updated their lupus anticoagulant (LA) detection guidelines. The Clinical and Laboratory Standards Institute (CLSI) subsequently will publish its first LA guideline. General agreement exists on issues such as sample preparation, the use of dilute Russell vip...
متن کاملPhlebotomy issues and quality improvement in results of laboratory testing.
Laboratory testing is an integral part of the decision-making process, and results of laboratory testing often strongly influence medical diagnoses and therapies. There is a long history of quality requirements in laboratory medicine, which have mainly concerned the analytic phase of this process. Owing to the substantial advances in technology, laboratory automation and analytic quality, there...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2007
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2007.089524